Endocrine Abstracts

Background: Identifying hypertensive patients with primary aldosteronism (PA) using the aldosterone to renin ratio (ARR) is crucial for optimizing their treatment. Various medications used to treat hypertension are known to alter levels of aldosterone and renin, thus affecting the ARR. As withdrawing all medication before screening is often unrealistic, we aimed to determine the degree of interference of some commonly used agents on the ARR using assays on the automated IDS-iS...

The screening for primary aldosteronism (PA) is based on the aldosterone/renin ratio (ARR), which is calculated with the plasma renin activity (PRA) as denominator. A direct measurement of active renin (DRA) is being used as an alternative to PRA, but its diagnostic performance remains uncertain.Aim of the study was to head-to-head compare the ARR based on PRA (ARR-P) to on DRA (ARR-D), at baseline and post-captopril, for identifying aldosterone-producin...